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Linda Birnbaum didn't have toxicology in mind when she graduated from high school. But a solid education and years of experience in research led to her current position as director of the environmental toxicology division of the U.S. Environmental Protection Agency (EPA).

"It's the sort of happenstance occurrence that can happen in any field," she says. "I was doing research at a small, nonprofit institution on drug metabolism when I discovered an interest in toxicology."

Birnbaum earned a bachelor's degree in biology from the University of Rochester and a master's and doctorate in microbiology from the University of Illinois.

Prior to joining the EPA in 1990, Birnbaum was head of the chemical disposition group at the National Institutes of Environmental Health Sciences. She's also adjunct professor at the University of North Carolina, a member of numerous professional societies and editorial boards, and has presented more than 50 national and international talks since 1989.

Toxicology also sort of evolved into a career for Donn Kushner. "I didn't choose to be a toxicologist as such, but wanted to be a biochemist," says Kushner, director of a collaborative program in toxicology.

"Then I became a biochemist who worked on interactions of micro-organisms with toxic substances, including antibiotics and extreme environments."

What interests Kushner most is the resistance developed by microbial and insect pests to drugs and insecticides that previously worked against them. The Louisiana native has a bachelor's degree in chemistry from Harvard and a master's and a doctorate degree in biochemistry.

Ohio native Halle Weingarten wanted to be a physician. Initially a pre-medicine major at Case Western Reserve University in Cleveland, she changed her major and later earned a bachelor's degree in biology.

It was a part-time job in the county coroner's office during her senior year that sparked an interest in toxicology. Now Weingarten is a forensic toxicologist with her own consulting business in San Jose, California.

"The coroner's office and lab work really sparked my interest. I was there for four years before I found a graduate program with what I wanted in toxicology....[I] got my master's in pharmacology with a focus on forensic toxicology."

Weingarten found her way to San Jose when she was offered a position with the county's crime laboratory. She was its chief of toxicology for 19 years, then directed a private lab in Southern California for one year before returning to San Jose to start her own business.

Consulting for defense attorneys, crime labs and the U.S. Department of Transportation keeps Weingarten busy. She also serves as recording secretary of the California Association of Toxicologists.

The experimental nature of toxicology attracted Keith Solomon. Solomon, director of the Center for Toxicology, says he's always been interested in the interaction between substances and organisms.

Solomon earned an undergraduate degree in chemistry, a master's degree in zoology and his doctorate in entomology. He writes, researches and teaches courses on aquatic ecosystems and waterfowl, and on the effects of "hormone mimics" and chlorine compounds.